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In recent years, as pharmacological studies have advanced, the functional applications of Stevia in both pediatric and adult populations have shown promising prospects

Interestingly, both kinase DYRK1A and Akt have convergent effects by directly inactivating GSK3 by phosphorylation at Thr356 (for DYRK1A) (Song et al., 2015) and on serine 9 (for Akt) (Tlili et al., 2013

Most TCSs consist of a sensor histidine kinase and a response regulator (RR), wherein histidine kinase senses environmental signals and auto-phosphorylates on a conserved histidine residue, transferring the phosphate group to a conserved aspartate residue of cognate RR, thus regulating gene transcription to generate cellular response [232]

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Typical neuropathological features of AD include the deposition of beta-amyloid (A) into neuroinflammatory plaques, intracellular aggregates of Tau protein in neurofibrillary tangles, synaptic loss, neuroinflammation, and neuronal death