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Together, these challenges highlight the need for refined tools, integrative methodologies, and cautious interpretation of data when advancing microglia-targeted therapies into clinical use

The body composition changes patients see are downstream effects of better metabolic function, not direct fat loss

doi: 10.3389/fnins.2016.00243

Studies on cultured human retinal pigment epithelial cells (a component of the outer BRB) show that fenofibric acid reduces LDLox-induced plasma leakage to the retinal interstitium [35]