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A key feature of the cellular response to hypoxia was the intracellular distribution of the mitochondrial network, which contributed to hypoxic signaling via HIF activation and was regulated by cross-talk between CHCHD4 and HIF-1

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The cytosolic O-acetylserine(thiol)lyase gene is regulated by heavy metals and can function in cadmium tolerance

The transgenic Col1a1 tm1jae (Col R ) mice have a mutation in the collagenase cleavage site of the 1 chain of collagen type I, and as a consequence of the reduced collagen turnover they accumulate collagen in various tissues