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The mixture was incubated in an aluminium box under 20 watt lamp for 7 min

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Engagement of BDNF with TrkB mainly regulates neuronal survival, differentiation and plasticity, while p75NTR can act pro-apoptotic but can also promote cell survival ( Figure 1 Indeed, data on BDNF levels in MS-patients showed conflicting results, as some authors described increased, decreased and some unchanged levels in the disease ( BDNF expressing cells are more numerous in actively demyelinating areas and TrkB is upregulated near MS plaques as was shown in a human post-mortem study ( in vivo studies demonstrate that in the absence of BDNF, mice experienced a stronger disease course in experimental autoimmune encephalomyelitis, EAE, the animal model of MS ( BDNF has been shown to play an important role in remyelination