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10.1002/ana.22052 83 Garca-CasaresN.Gallego FuentesP.BarbanchoM.Lpez-GigososR.Garca-RodrguezA.Gutirrez-BedmarM

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Early studies suggest that DSIP may have potential benefits not only for sleep quality but for the central nervous system, cortisol levels, physical recovery and brain health also

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2 These include: A ME/CFS-like phenotype with post-exertional malaise and impaired bioenergetics A dysautonomia/POTS-dominant presentation A mast celldriven inflammatory phenotype Persistent cardiopulmonary injury This heterogeneity explains why a single treatment approach fails