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These findings indicate that HDACs, particularly HDAC6 inhibitors, mitigate UA-induced endothelial dysfunction by upregulating FGF21, which in turn activates the PI3K/AKT pathway

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Theory of Ageing Causes Ageing is characterised by a progressive loss of physiological integrity that impairs function, increases vulnerability to stress and disease, and ultimately culminates in organismal mortality [12]

[10] Knowledge of the subtype is helpful in determining treatment strategies

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