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The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival

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It is mostly caused by the mutation of the trinucleotide CGG expansion in the 5-untranslated region of the fragile X mental retardation ( FMR1 ) gene, which eventually leads to the absence of its protein product, fragile X mental retardation protein (FMRP) (Garber et al., 2008

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