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Weitzberg E, Hezel M, Lundberg JO

Quinn, B

The study, published in Frontiers in Pharmacology, found that Metformin activates a protein known as AMPK

Postmortem analyses have confirmed astrocyte activation in the substantia nigra of PD patients, accompanied by elevated pro-inflammatory cytokines [tumor necrosis factor- (TNF-), IL-1, transforming growth factor-, and IL-6], ROS, NO, pro-apoptotic proteins, and T-cell infiltration