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The combination therapy with immune checkpoint blockade potentially offers promising strategies in improving cancer treatment efficacy and patient survival rates

Guan, M., Xu, W., Bai, H., Geng, Z., Yu, Z., Li, H., & Liu, T

Furthermore, it has been shown that PQ enhanced Ang II and collagen type I mRNA and protein expression and the increased chymase that converts Ang I to Ang II which is closely involved with lung fibrosis, expression in PQ-treated human lung fibroblasts, and it was confirmed in vitro and in an in vivo PQ model of lung fibrosis that chymase generates Ang II and enhances collagen expression (Lang et al

However, in hypoxic environments, VHL cannot mediate the ubiquitination of HIF-1 due to the lack of prolyl hydroxylase domain (PHD) proteins to multi-ubiquitinate or hydroxylate proline residues, resulting in metabolic changes (115)

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