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Collectively, these factors highlight the need for carefully designed therapies that can selectively target GSH in tumors while minimizing toxicity and overcoming adaptive resistance mechanisms

Gu SS, Yu P, Hu JN et al (2019) Mitochondria-localizing N -heterocyclic thiosemicarbazone copper complexes with good cytotoxicity and high antimetastatic activity

G.GarmendiaC

JUrol 2019] 3) Pine bark (Pycnogenal) - This supplement is made from the French maritime pine tree bark extract and is felt to have antioxidant properties

Using ferroptosis as an example, the mouse p53 mutant with substitutions at K117, K161, and K162 (hereafter referred to as p53 3KR/3KR) can activate ferroptosis and suppress tumor growth