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Nat Commun 15 , 4244 (2024)

While peripheral antioxidant measures (catalase and GSH/GSSG) increased significantly relative to baseline, indicators of oxidative damage, i.e., measures of lipid peroxidation (4-HNE and MDA) were unchanged

4.6.5 SIRT1/PGC-1 pathway The Sirtuin 1/PPAR- co-activator1 (SIRT1/PGC-1) pathway is critical in regulating mitochondrial function and OS, which are key factors in the pathogenesis of DN