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Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death

In relapsed/refractory Hodgkin lymphoma following checkpoint treatment, the combination of the JAK inhibitor ruxolitinib with nivolumab resulted in a 53% response rate, decreased immunosuppressive myeloid cells, and revitalized depleted T cell performance [98]

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