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Lipase can also affect local pancreatic blood flow and induce edema, contributing to further tissue necrosis and exacerbating the pathology ( Furthermore, it is crucial to explore the relationship between lipase activation and inflammatory pathways beyond necrosome formation, specifically the interaction with the NLRP3 inflammasome ( Additionally, the buildup of fatty acids is a significant pathological phenomenon in AP

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TB-500 corresponds to its central active 17-mer fragment (sequence LKKTETQ), responsible for most pro-regenerative effects