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In chronic tinnitus and neurodegenerative diseases, dysfunction of the Nrf2/ARE pathway has been increasingly recognized as a critical factor contributing to the collapse of endogenous antioxidant defenses (Scuto et al., 2020

Together, these studies demonstrate that TJ proteins are regulated by cytokines, modify intestinal permeability and are linked to disease pathogenesis

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For most people who report a "copper uglies" phase, the described outcome is mild and resolves without intervention