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Public health efforts should also emphasize targeted education, early screening, and environmental control policies in high-risk regionsparticularly those affected by combined air pollution and occupational exposures

Notably, the use of the cell-permeable copper complex Copper2+-glyox albis(N4-methylthiosemicarbazonato) [Cu2+(gtsm)] mitigated AD-like changes by promoting GSK3 inhibition, reducing tau phosphorylation and decreasing A oligomers, highlighting its potential as a therapeutic strategy for safe and bioavailable copper supplementation (89)

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