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AZD-6094Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC s of 5 nM and 3 nM for c-Met and p-Met, respectively

Specifically, redox proteomics identified oxidative modification by HNE of many enzymes associated with glucose metabolism, including those associated with glycolysis, the Krebs cycle, and the electron chain of mitochondria (6, 15, 25, 29, 124, 125, 131134)

Cautious use is warranted for patients with other types of GI disease such as inflammatory bowel disease (ulcerative colitis, Crohns disease), as these conditions may be exacerbated

Eating smaller meals, avoiding high-fat foods, and staying hydrated help manage it

Available: [5] L