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doi: 10.1007/s10265-022-01420-w 24 ChengL.WuF.BaoH.LiF.XuG.ZhangY.et al

My buddy gave me a lift here, uh, today on his plane, and he's a very wealthy, successful guy, but he was getting riled up about some trans thing and an issue

This paper shows that owing to the proximity of SMAD4 and ME2 in the genome, SMAD4-mutated pancreatic ductal adenocarcinoma cells also show loss of ME2, and are therefore more dependent on ME3 to generate NADPH