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Additionally, metal ion metabolism disturbances are the basis for the onset of various neurological diseases [175]

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Code A represents a high quality of evidence, B represents a moderate quality of evidence, C represents a low quality of evidence, and D represents a very low quality of evidence, while number 1 stands for a strong level of recommendations and number 2 stands for a weak level of recommendations

Mol Med Rep (2019) 19:205764

The addition of ImmTOR to pegadricase results in a dose-dependent reduction in ADAs corresponding with prolonged serum enzyme activity and maintenance of low sUA levels