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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

These results for the model complexes have important implications for understanding experimental results

Similar content being viewed by others Facts Melatonin is a ubiquitous molecule with natural and powerful antioxidant proprieties and administration of exogenous melatonin is safe Melatonin exerts anti-inflammatory effects mainly by inhibiting inflammasome activation Melatonin exerts its antiapoptotic activities mainly by blocking caspase 3 cleavage and mPTP opening Oxygen radical diseases of neonatology refers to the oxidative stress that has a leading role in the pathogenesis of neonatal morbidities and pathologic conditions Open questions How endogenous melatonin contrast the oxidative stress that has a leading role in the pathogenesis of neonatal morbidities and pathologic conditions

Peer review Peer review information Nature thanks Tony Hunter and the other, anonymous, reviewer(s) for their contribution to the peer review of this work