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Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

With MOTS-C running alongside, the infrastructure scales to match the demand

This quantitative difference reflects that most transmitter uptake, especially that of glutamate, occurs in astrocytes and that on average two thirds of astrocytically accumulated neuronal transmitters are recycled to neurons, whereas the last one third is oxidatively degraded, mainly or exclusively in astrocytes