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doi: 10.1186/s13046-024-03032-9 37 GuoJXuBHanQZhouHXiaYGongCet al

( [12] Hooshmand B, et al

doi: 10.1042/BCJ20200937 42 FukudaMKannoEIshibashiKItohT

The morphological characteristics of ferroptosis include the rupture of cell membranes, but chromatin condensation is lacking in the cell nucleus ( Definition and Process of Ferroptosis The term ferroptosis emerged in 2012 to describe the form of cell death triggered by the small molecule erastin, thereby inhibiting cystine import, triggering the inactivation of phospholipid peroxidase glutathione peroxidase 4 (GPX4) and consumption of glutathione (Xie et al., 2019)