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H 2 S could perform a nucleophilic attack on oxidized protein cysteine residues either as sulfenic acid, disulfide bond or glutathione adducts ( 2 S, the resulting persulfide being reduced by Trx ( 2 S is a poor reductant compared to glutathione and that it is also less abundant and reactive

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In patients with CKD, the expression of PPAR is positively correlated with renal function indicators such as the estimated glomerular filtration rate (eGFR), suggesting that PPAR may play an important role in maintaining renal function and has great potential as a biomarker [119]