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LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension

reported that the pretreatment with -glucans extracted from Ab presented protective effect in human hepatic cells against the genotoxic and mutagenic effects of carcinogenic compound (Benzo[a]Pyrene) ( In septic patients, MDA levels are elevated and may be correlated with clinical worsening ( In relation to the antioxidant defense, decreased levels of GSH and the inhibition of total antioxidant capacity are associated with organ failure and high mortality in sepsis ( Ab -treated animals showed increased TEAC and GSH levels in serum and peritoneal cavity, and also enhanced antioxidant capacity in heart in liver tissues, as well as increased MDA/TEAC ratios in serum, peritoneal cavity, heart and liver, suggesting that the protective effect of Ab in CLP model is at least in part due to its antioxidant property

Patients also completed the Prognostic Treatment Perceptions Questionnaire to assess their readiness to discuss prognosis and self-reported health status

Guzik TJ, West NE, Black E, McDonald D, Ratnatunga C, Pillai R, et al

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