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In addition, 496 metabolites could be assigned to classes by comparison to the HDMB (Supplementary Figure 4A)

Further to this, calmodulin kinase II (CAMKII) and phospholipase D (PLD) were shown to be major pathways responsible for the polymerisation of actin 71

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Nevertheless, pulmonary function tests can show some reduction in vital capacity, expiratory reserve volume, pulmonary compliance, and airway resistance (338, 339)