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Description

Polymorphisms in NQO1 can lead to decreased reduction of the catechol estrogen quinones back to catechol estrogens 33 , again leaving more quinones available to react with DNA, unless they are removed by reaction with GSH

Nano-targeted delivery of RSV to LSECs and that of TNS to HSCs synergistically suppressed HCC growth in mouse fibrotic HCC models, accompanied with the alleviation of fibrosis and the increased infiltration of M1 macrophages and effector CD8+ T cells in tumor lesions, suggesting that RSV and TNS exert anti-HCC effect by improving tumor immune suppressive microenvironment