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doi:10.1128/AEM.02173-12

This suggests that CD38 might be a potential additional immunotherapeutic target in HCC and NSCLC, and can be used together with PD-1/PD-L1 immunotherapy ( Reasons for Choosing CD38 as a Therapeutic Target The main reasons why CD38 has become a tumor treatment target are as follows: (1) In a hypoxic TME, CD38 acts as an extracellular enzyme to catalyze NAD + existing in the TME into ADPR or cADPR

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J Urol 182:14531457 Gilat M, Marshall NS, Testelmans D, Buyse B, Lewis SJG (2022) A critical review of the pharmacological treatment of REM sleep behavior disorder in adults: time for more and larger randomized placebo-controlled trials