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MRS data processing Phantom solutions (0.55 mM GSH, 5 mM DTT, 10 mM Choline, 25 mM Creatine, phosphate-buffered saline, pH 7.1) were used to validate [GSH], [Cr], and [Cho] quantification by MRS, using the water peak as a standard

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Unfortunately, despite the remarkable progress in preclinical studies, research on these targets and signaling pathways has mainly remained in the animal and cellular experiments stage and has not yet entered the clinical trials stage

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The antibodies utilized in this experiment are listed in Table S2 (Additional file 1)