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For instance, a 6-week study in 66 people with type 2 diabetes found that taking 30 grams of glutamine powder daily improved multiple risk factors for heart disease and reduced both belly and body fat ( Similarly, a 2-week study using the same amount of glutamine observed decreased waist circumference, a marker for belly fat, in 39 people with overweight or obesity ( In another small study, 6 women who took glutamine supplements for 4 weeks experienced significant reductions in body weight and belly fat without making other dietary or lifestyle changes ( Yet, a study in 24 adults indicated that taking 6 grams of glutamine led to an increase in meal size, which may hinder weight loss ( Moreover, another study that examined the effects of taking a glutamine supplement in combination with exercise noted no benefits for body composition or muscle performance ( Keep in mind that all of these studies used very small sample sizes and only evaluated the short-term effects of glutamine supplements

Reactive oxygen species (ROS) activate intracellular signaling cascades that stimulate pro-inflammatory gene expression, while activated immune cells further generate ROS and inflammatory mediators (e.g., cytokines, chemokines), amplifying tissue injury at inflammatory sites [116]

In: Lipophilicity in drug action and toxicology