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Conditional deletion of Atg5 in OPCs precipitates apoptosis, inhibits differentiation, and results in significant hypomyelination, with surviving cells exhibiting cytoplasmic retention, swollen inner tongues, and myelin outfoldings

Gating strategies are shown in Extended Data Fig

In addition, some peptides have FDA-approved medical uses, while others are prescribed off-label or remain investigational for wellness, performance, or longevity purposes

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5.2 FSP1-CoQ/DHODH-CoQ/GCH1-BH4/Nrf2-Keap1 signaling pathway In the last few years, three GPX4-independent signaling pathways have been identified to inhibit ferroptosis: Ferroptosis Suppressor Protein 1 (FSP1)/CoQ10, Dihydroorotic acid dehydrogenase (DHODH), and GTP Cyclic Hydrolyserase 1 (GCH1)/Tetrahydrobiopterin (BH4)