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For competition binding assays, cell lysates were incubated with the indicated concentrations of DA, NE, yohimbine, or clonidine and 0.40.9 nM [ 3 H]RX821002 (90 min, room temperature)

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The differences between these studies may be explained by variations in the recruitment (mean age, inpatients or outpatients, studied departments) and the threshold defining the status of elevated B12

These data suggest that a decrease in GSH alone can act as a potent early activator of apoptotic signaling

232 Several studies have demonstrated that loss of function of UBE3A leads to increased ARC expression and subsequently decreases the number of AMPARs, ultimately impairing synaptic plasticity at excitatory synapses