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If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use

This analysis highlights the molecular scaffolds to which the model is most sensitivesuch as aliphatic esters for fruity, terpenes for citrus, and fused tricyclic frameworks for woody notes

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These observations of a 40% to 50% reduction in LDL-C concentrations in models of LDLR deficiency are well-aligned with the results of clinical trials of the evinacumab and zodasiran ANGPTL3 targeted therapies in patients with HoFH described above

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