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Specifically, the remarkable amino acids dysregulation observed in this study is consistent with previous works reporting altered blood or CSF concentration of glutamic acid, glutamine, glycine and serine in PD patients compared to HC 5,13,22,24,25

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RSL3 is a chloroacetamide-containing covalent ligand with two stereocenters, with only one of four stereoisomers displaying highly potent GPX4 inhibition 39

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