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Furthermore, histopathological observations on both H & E staining and Oil red O staining demonstrated serious hepatic steatosis and cardiac tissue damage with lipid droplets in HM groups contrasted to the control group due to higher lipid profile and increased cellular toxicity marker such as ALT, AST, ALP, LDH and CK-MB level

The wide variability in reported outcomes reinforces the dose- and context-dependent nature of NP-plant interactions and highlights the need for long-term, integrative risk assessments [241, 242]

Polyphyllin -Induced ferroptosis in MDA-MB-231 triple-negative breast cancer cells can Be protected against by KLF4-mediated upregulation of xCT

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