glutathione supplementation for friedreich's ataxia Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review Recessive cerebellar and afferent ataxias

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Am J Clin Nutr 92:525531

Figure 1: Chemical structure of Glutathione [source: Accessed: 10 Oct 2012] The presence of the reactive sulphydryl group (originating from the cysteine residue) gives rise to GSHs nucleophilic nature and so it reacts readily with electrophiles which can present high risk of toxicity to the cell by causing oxidative damage such as lipid peroxidation to cell membranes, and interfering with the activity of essential proteins and DNA synthesis

Encapsulation of DDA-GSH-AuNCs into PLGA nanoparticles using the emulsion-evaporation method PLGA (30 mg) was dissolved in chloroform containing DDA-GSH-AuNCs (1.5 mL), and then emulsified into aqueous PVA solution (2.5% w/w, 5.0 mL) using sonication for 60 s (ultra-probe sonicator at 50 W, UP200Ht, Hielscher Ultrasonics, Teltow, Germany)

NOx affected the level of glutathione after the shortest and the longest duration of seed ageing The concentration of GSH in the axes isolated from embryos of apple seeds subjected to ageing for 7 days, after 48 h of embryo culture, was approximately 445 nmol g 1 FW and did not change significantly during prolonged ageing (Fig