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1 In vitro cell culture The development of in vitro cell culture techniques in the early 20th century revolutionized life sciences by enabling scientists to study cellular behaviour, physiology, and responses in a reproducible and manipulable environment (Subbiahanadar Chelladurai et al., 2021), and this has provided indispensable tools for cancer research, drug screening, vaccine production, and regenerative medicine (Segeritz CP, 2017