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The high fiber content and the presence of lignin and detergent fibers that are neutral and acidic in nature suggest that cocoa bean shells are better suited for ruminants than monogastrics

In addition, Ca 2+ -activated calcineurin activates lysosomal biogenesis by phosphorylating TFEB (transcription factor EB)

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However, like many supplements, it may cause side effects in some individuals, particularly at higher doses or when combined with other compounds

[DOI] [PubMed] [Google Scholar] Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y et al (2012)