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Lipid-laden adipocytes produce increased levels of cytokines such as Interleukin 6 (IL-6), IL-, TNF-, monocyte chemoattractant protein-1 (MCP-1), and IL-8 [10, 56, 57] which can inhibit preadipocyte differentiation [21, 45]

SIRT1 activation also promotes fatty acid oxidation, reduces lipogenesis, improves insulin sensitivity, and enhances cellular stress resistance

Oral administration introduces complications

Serum creatinine levels increased during treatment

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