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2023;6:e2256004ArticlePubMedPMC 6

These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)

Matsuno K, Yamada H, Iwata K, Jin D, Katsuyama M, Matsuki M, Takai S, Yamanishi K, Miyazaki M, Matsubara H, Yabe-Nishimura C

DOSAGE The following dosage recommendations apply unless otherwise prescribed: At the start of treatment, in the first few weeks after diagnosis, 1 ampoule of VITAMIN B12 Depot Panpharma (corresponding to 1000 ug hydroxocobalamin acetate) is administered twice a week

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