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The authors of the study noted that these improvements were the opposite of the changes that would normally occur over a 10- to 20-year aging period

At the 52-week mark, average weight loss was 19.5% of total body weight

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While hyperhomocysteinemia may increase the risk of cognitive impairment and age-related neurodegenerative disease (e.g., Alzheimers disease), it is not clear whether vitamin B 12 deficiency contributes to the risk of dementia in the elderly