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Several studies have explored co- or pre-treatment with vitamin D in response to various pollutants

Danger signals, including cartilage degradation products, are recognized by synovial macrophages, activating pathways such as NF-B and triggering the release of pro-inflammatory cytokines (e.g., IL-1, TNF-, and IL-6) and chemokines

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CoQ10 scavenges free radicals produced by lipid peroxidation and prevents mitochondrial deformity during ischemic episodes, and may help maintain integrity of myocardial calcium ion channels during ischemic insults (2)