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Using nuclear magnetic resonance (NMR)-based metabolomics and mass spectrometry-based proteomics, significant alterations in metabolic and protein expression profiles associated with resistance were identified

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This movement is caused by cellular swelling and a relative narrowing of extracellular gaps, which in turn generate slow-conducting waves of depolarization in multiple neurons and glial cells, resulting in the temporary inhibition of synaptic activity (Kowalska et al., 2021)

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