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Layer these with iron metrics that determine OH propensity, such as calcein-quench assays for the labile iron pool (validated by reversible de-quenching with chelators) and markers of iron handling (ferritin levels, HO-1 induction and ferritinophagy readouts like NCOA4), because shifts in iron biology can transform benign H 2 O 2 into damaging OH

doi:10.1016/j.msec.2018.10.093 157

Tissue Eng B Rev 17:165176 Lovric-Bencic M, Sikiric P, Hanzevacki JS, Seiwerth S, Rogic D, Kusec V, Aralica G, Konjevoda P, Batelja L, Blagaic AB (2004) Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse

doi: 10.1210/jcem.85.12.7053 58