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454 Moreover, centrally mediated factors, such as cognitive processes (e.g., attention, distraction, catastrophizing), contextual beliefs about pain, and emotional states (e.g., depression, anxiety), significantly influence the pain experience

Chen M, Tian H, Huang G, Fang T, Lin X, Shan J, et al

They work by inhibiting the production of thyroid hormones

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Similarly, the RPM supplementation for cows during late pregnancy induced a rapid maturation of gluconeogenesis and fatty acid oxidation pathways in the offsprings liver at birth, which could favor the metabolic demands in postnatal life (Jacometo et al., 2016)