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Therefore, if you are on tamoxifen it may be best to avoid turmeric and curcumin (particularly in concentrated supplement form), as it can lower the concentration of endoxifen in the body such that it interferes with the therapeutic impact of the drug

* Correspondence: Remigiusz Domin, [email protected] These authors have contributed equally to this work and share senior authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, high dose oral vitamin B12 therapy can also be effective, provided that the dose is sufficient, medication adherence is good, and a response is documented

Take with food, ideally in the morning or at lunch

IJBAMR 1(9):1826 Kim J et al (2019) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes