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doi: 10.3389/fimmu.2019.01662 26 Ochoa-ReprazJMielcarzDWDitrioLEBurroughsARBegum-HaqueSDasguptaSet al

This effect was likely mediated by the spino-olivocerebellar tract, which ascends via the dorsal and dorsolateral funiculi to deliver nociceptive input directly to cerebellar circuits (28, 62)

Steroids are hormone-based compounds with different mechanisms and effects

While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest