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It means that, for example, certain therapies can have difficulty penetrating the brain

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Indeed, in many proliferative cell types, the oxPPP is required to generate ribose-5-phosphate for nucleotide synthesis, whereas G6PDH-deficient chondrocytes can produce this metabolic intermediate by rewiring glucose carbon flux through the non-oxPPP (Fig

The APP Dutch mouse model, carrying the E693Q mutation (APP751) under the murine Thy1 promoter, exhibited no neurofibrillary tangles (NFTs) or amyloid plaques

Ensuring equitable access to these services for all individuals, irrespective of socioeconomic status, is essential