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In contrast to HmbR, which preferentially but not exclusively recognizes human hemoglobin, TbpA/TbpB and LbpA/LbpB recognize exclusively human transferrin and lactoferrin, respectively, and this selectivity strongly contributes to the narrow host spectrum of the meningococcus (Perkins-Balding et al., 2004)

For instance, gene editing technologies like CRISPR-Cas9 present exciting possibilities for addressing age-related diseases, but concerns regarding off-target effects, long-term safety, and the ethical implications of genetic modifications need to be thoroughly addressed before such interventions can become mainstream (Caobi et al., 2020)

Heliyon, 9 (7), e18288

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