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Butterworth JF et al (2018): Neuromuscular Blocking Agents (Chapter 11)

In summary, animal studies show that hypoxemia results in pulmonary vasoconstriction and normoxemia reduces PVR, but hyperoxemia does not enhance pulmonary vasodilation

A redacted version of the IMC-M113V-103 study protocol is included in the Supplementary Information file and available at CTIS - Clinical Trials in the European Union ( Cell-associated HIV gag RNA sequences generated in this study have been deposited in the BioSample database under BioProject PRJNA1372654 ( Source data are provided with this paper

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Tolerance to the neuroplasticity effects has not been documented in research models, meaning repeated dosing continues to drive synaptic remodeling without requiring higher doses to achieve the same receptor activation