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The duration of the trial was three years with 3862 patients exposed to Reclast and 3852 patients exposed to placebo administered once annually as a single 5 mg dose in 100 mL solution infused over at least 15 minutes, for a total of three doses

Antiparkinsonian medications, especially anticholinergics [102, 116], as well as several other frequently prescribed medications, such as opioids, tricyclic antidepressants, calcium-containing antacids, antihypertensives, spasmolytics, sympathomimetics, and diuretics, may also worsen constipation

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Clinical takeaway In complex chronic conditions: adding nutrients is often insufficient restoring information flow within the system is critical Sometimes, a simple fermented matrix can act more deeply than multiple supplements