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We observed knockdown of NRF2 protein and robust growth inhibition upon dox treatment, highlighting the dependency of these cell lines on NRF2 for growth (Fig

Resveratrol acts as an antioxidant by scavenging free radicals, reducing oxidative stress, and decreasing reactive oxygen species (ROS)

STING activation has been shown to induce apoptosis 24,25 , necroptosis 26,27 , and autophagy 28 in leukemia cells

The elevated doses of exogenous ascorbate can inhibit germination through ROS elimination which results in failure of germination initiation (Takemura et al., 2010)